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How to combine creatine and caffeine effectively

Due to a study published by some researchers from my home country (Belgium) it was long commonly accepted in the bodybuilding world that creatine and caffeine should not be combined because caffeine negates the positive effects creatine supplementation has. However, a more recent study (Caffeine is ergogenic after supplementation of oral creatine monohydrate) has shown that there might be a way to effectively combine the beneficial effects of both creatine and caffeine as long as caffeine isn’t administered regularly. In this study, fourteen trained male subjects were supplemented with 5 mg of creatine for six days. As you can clearly see in this graph, in most subjects caffeine provided an additional boost in terms of total running time in most subjects:

Effects of creatine and caffeine supplementation on treadmill running time

Physical exercise reduces the amount of ATP (the molecule your cells use as fuel) in muscle cells. As a result the enzyme AMPK becomes more active in muscle cells, which triggers them to start burning fat and become more sensitive to insulin. It shouldn’t surprise you that researchers everywhere are working on pills that activate AMPK, as this could mimic the effects of doing sports without even having to get out of bed. A Japanese study (Caffeine acutely activates 5’adenosine monophosphate-activated protein kinase and increases insulin-independent glucose transport in rat skeletal muscles) discovered that caffeine raises AMPK but at the same time decreases the creatine content in muscle cells. Although the concentrations the researchers used are much higher than the those found in the human body, it seems to indicate that caffeine disrupts the muscle cell’s creatine metabolism.

In conclusion; if you are supplementing creatine, regular high doses of caffeine will cancel out its effect. However, you might be able to benefit from the performance boost provided by both creatine and caffeine provided you limit your intake of the latter to about once a week.

Disclaimer: there is limited research on this subject so although this is the best answer currently available, take it with a grain of salt.

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How to maximize creatine absorption?

Creatine absorption and citric acid

It’s usually recommended not to mix creatine with acidic drinks such as grapefruit or orange juice since the citric acid might prevent creatine from being absorbed effectively. Others argue that, the effect of citric acid on creatine is minimal considering creatine will also be exposed to the stomach which is a much more acidic environment, and since creatine survives stomach acid it can also be mixed with acidic beverages without significant degradation as long as you consume them within a few hours after mixing.

Let’s get our facts straight. According to the study “The creatine-creatinine equilibrium. The apparent dissociation constants of creatine and creatinine“, after 25 hours in a solution with a pH of 1, only 2% of creatine is degraded to creatinine. Apparently, degradation is highest when creatine is exposed to a pH between 2 and 5. Considering the acidity of liquids that people usually do not recommend such as grapefruit juice (pH 3.2) isn’t that different to that which people do recommend such as grape juice (pH 3.4), I’d conclude it doesn’t really make too much of a difference.

Creatine absorption and water

You’ve probably been told not pre-mix your creatine since it will break down over time when dissolved in a liquid. The problem is that there doesn’t seem to be a consensus regarding the exact time it takes for creatine to be degraded to the waste product creatinine, some claiming degradation could take effect in as little as 30 minutes and others that creatine levels do not decrease much for at least a day or three. If you want to play it safe, drink the mixture as soon as possible after dissolving the creatine. There are shakers available with separate compartments so this should not prove to be a major hassle.

Creatine absorption and baking soda

Baking soda, a surprising supplement.

According to the study “Combined creatine and sodium bicarbonate supplementation enhances interval swimming“, creatine’s effects might be amplified by combining intake with  sodium bicarbonate commonly known as baking soda. This is a little know fact, probably because supplement companies can’t make money off a cheap universally available cooking ingredient.

Its synergy with creatine isn’t the only benefit offered by sodium bicarbonate, by the way. Here are some other studies suggesting increased sports performance at the recommended dose of 0.3 g per kg of bodyweight taken 60 to 90 minutes before a workout;

  • +34% time to exhaustion and +91% total work during HIIT (Feb 29, 2012)
  • Synergistic and superior effects compared to beta alanine (Feb 20, 2012)
  • Protection against stress induced damage to white blood cells (Nov 28, 2011)
  • Increased performance in tennis players (Nov 4, 2010)

Creatine absorption and food

It’s best to take creatine on an empty stomach for several reasons;

  1. The ingestion of a meal will decrease the acidity of the stomach drastically to the pH levels at which creatine is broken down at the fastest rate as previously mentioned.
  2. Food sitting in your stomach will slow down the absorption of creatine, meaning it will be exposed to these less-than-ideal pH levels for a longer period of time.

Update May 2014: a new study seems to show that sodium bicarbonate has very limited effect on performance. Only during the first exercise of a workout was there a significant difference compared to placebo. They also stress that the health risks associated with increased sodium intake are probably not worth the small boost in exercise performance.

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Can creatine and caffeine be combined effectively?

Effects of supplementing creatine and caffeine simultaneously

Many people using pre-workout supplements ask if creatine and caffeine can be combined effectively. It’s a valid question considering creatine and caffeine are often combined in popular pre-workout products such as MusclePharm’s Assault,  BSN’s N.O.-Xplode, Bentancourt Nutrition’s Bullnox, UPSlabs Jack3D or BPI Sports’ 1.M.R. Unfortunately, there is still a lack of studies to either fully confirm or debunk the fact that caffeine influences the effect creatine supplementation has on strength training.

Examine.com has evaluated the results from various studies and also concludes that the effects of co-ingesting creatine and caffeine are not yet clear:

Co-ingesting creatine with Caffeine appears to partially negate the benefits of creatine supplementation (at 5 mg/kg bodyweight) during the loading phase. The exact mechanism is not known, but might be related to opposing actions on muscle contraction time.

However, caffeine does not negate the benefits of creatine loading when not co-ingested, but just taken before exercise in the same dosage. This result indicates that loading creatine without caffeine on a daily basis, but saving caffeine for select workouts, may be an effective strategy as creatine does not adversely affect Caffeine’s ergogenic effects and may enhance creatine’s effectiveness in anaerobic exertion if the two compounds are alternated.

For more information regarding recent research, also read my article on how to combine creatine and caffeine effectively.

Caffeine’s effects on creatine absorption

Does caffeine influence the absorption of creatine? Again, due to lack of scientific studies, the short answer is “we’re not sure”.  If you wish to use both, perhaps the best solution until more information becomes available is to play it safe and use caffeine as early as possible in the morning and load up on creatine later in the day. As you are probably aware, creatine is shuttled to muscle cells more effectively when combined with a carbohydrate-rich beverage, so I would recommend drinking some grape juice or some pure glucose with your daily dosage of creatine.

Also read my article on how to maximize creatine absorption.

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Guide to nutrient selection and nutrient timing

Let me start with a disclaimer: the tips provided on this page and the studies referenced are not necessarily 100% conclusive. The human body is an extremely complex machine and there are so many variables that nutritional science will likely always be a hot topic of debate. However, all nutrients listed are natural compounds that have been known and used for decades if not centuries, and will not do you any harm. Most of them are easy to obtain and relatively cheap, so you can rest assured that I’m not trying to promote any specific brand or product. These are just tips based on research and personal experience, meant to optimize nutrient selection and nutrient timing, which might have beneficial effects on your progress.

Nutrient timing: Best post-workout macronutrients

Whey is an excellent choice as pre- and post-workout protein source

Whey is an excellent choice as pre- and post-workout protein source

Protein: Obviously your muscles will require amino acids to start rebuilding the damage training caused. Ideally you already have some floating around in your bloodstream from a pre-workout shake or protein-rich meal, but studies show that an intake of 20 grams of protein every three hours (up to four times) after training is better at helping men build lean body mass than eating smaller amounts of protein more often.

Since research has shown contradictory results regarding the most important factor being timing of intake, protein quality, speed of absorption, combination with carbs, my conclusion is that various factors are at work and different people might react differently. What seems to work best for me and is most convenient is to take 20 grams of whey before exercising since it digests easily, another 20 grams after my workout along with a glucose-laden drink, and then have regular meals the rest of the day with at least 20 grams of protein each every 3 hours or so.

Glucose Powder is universally available and dirt cheap.

Glucose Powder is universally available and dirt cheap.

Carbohydrates: A lot of controversy exists around the topic of whether or not you should combine your post-workout shake with carbohydrates and if so, which kind. Most athletes and most notably bodybuilders seem to agree that it’s best to carbs which rate high on the glycemic index to create an insulin-spike which transports nutrients to your muscle cells which are hungry for nutrients after a workout. Most bodybuilders use pure glucose (a.k.a. dextrose) which is available at most pharmacies or large supermarkets.

Studies do not seem to be conclusive about the benefit of rushing glycogen replenishment. Some argue that over a 24-hour span glycogen stores will be replenished equally as long as carb intake is sufficiently high, regardless of them being absorbed quickly or gradually. Personally, I take  the route that seems most logical to me when research is inconclusive, which means I use high-GI carbs just after my workout and more complex carbohydrate sources such as pasta every 3 hours thereafter. I would recommend 25 to 75 grams of sugars depending on the duration and intensity of your workout.

Fat: After working out it’s best to avoid fat since it will slow down absorption of nutrients and as such their delivery to the muscle cells. In fact, it’s best to avoid high-fat meals for about 6 to 8 hours before the gym since you’re going to spike your insulin levels. Considering insulin triggers cells to take up nutrients and you want them to take in carbohydrates for energy and protein for muscle repair, it’s best to avoid too many fatty acids floating around in your bloodstream at that time, since the excess of nutrients and raised insulin levels will cause them to be stored as body fat.

Nutrient timing: Best post-workout micronutrients

β-alanine: According to the double-blind, placebo-controlled study study “Effects of β-alanine supplementation on performance and body composition in collegiate wrestlers and football players“, previously trained wrestlers taking 4 grams of β-alanine daily gained nearly twice as much lean muscle mass as the placebo group. More research is required since results were not statistically significant, but β-Alanine appears to augment performance and promote lean muscle mass in only 8 weeks.

Creatine: This is one of the few supplements that has conclusively been proven to improve resistance training performance by increasing the formation of ATP. Although the human body can synthesize creatine, supplementation significantly increases the levels of creatine stored in muscle tissue.  In 2004 the European Food Safety Authority (EFSA) stated that long-term supplementation of 3g creatine per day does not pose any health concerns. Extensive research has indicated that creatine supplementation up to 20 grams per day appears to be very safe and largely devoid of adverse side-effects. You should also know that caffeine might undo the positive effects of creatine to some extent, even though both are common ingredients in commercial pre-workout products.

Electrolytes: When this term is used in context of nutrition, one is usually referring to potassium and sodium. These minerals are commonly found in fruits and vegetables, notably coconut water has high quantities of potassium and makes an excellent natural sports drink. Commercial sports drinks usually combine electrolytes with sugars to promote absorption. I would recommend to check the label on these drinks to make sure that the sugar used is glucose rather than high-fructose corn syrup since fructose needs to be broken down by the liver whereas glucose can be oxidized directly.

Fenugreek: This is a plant commonly used in Indian dishes. A study performed in 2011 at  the Australian Centre for Integrative Clinical and Molecular Medicine concluded that men between the ages of 25 and 52 taking the extract twice daily for a total of six week scored 25% higher on tests meant to gauge libido in comparison to a placebo. This seems to indicate that fenugreek is somehow promoting testosterone levels. Scientists aren’t sure why fenugreek seems to have this effect on men, but one possible explanation is that the herb’s seeds contain saponins, which affect hormone levels. One particular saponin, called diosgenin, could affect production of sex hormones. According to another study “Therapeutic Applications of Fenugreek” there might be further benefits to supplementation such as ower serum trig- lycerides, total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C).

Curcumin: Although clinical trials are underway to study the effects of this compound, at this time there is not enough data to confirm its effects

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